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In our previous study, it was found that PAB induced L929 cells autophagy [7] and mitotic arrest [12] to inhibit L929 cell growth. But the time sequence of cell cycle arrest and autophagy was not focused. In this study, we found that PAB at 12 h induced obvious cell cycle arrest, and at 24 h PAB induced obvious autophagy. Therefore it was confirmed by us that cell cycle arrest was anterior to autophagy in the time sequence. It was reported that G2/M [30] or G1 [31] cell cycle arrest were related to autophagy, but our study confirmed that mitotic arrest was very important to autophagy. Meanwhile it was found that after 80 µmol/L PAB treated for 3 d, L929 cells became senescence, therefore in time sequence cell cycle arrest and autophagy were anterior to senescence..